Material Safety Data Sheet
MSDS Name: Acetone
Section 1 - Chemical Product and Company Identification
Dimethylformaldehyde; Dimethyl ketone; 2-Propanone; Pyroacetic acid;
Fisher Scientific Company, LLC
8365 Valley Pike
Middletown, VA 22645-0307
For information, call: 800-524-0294
Emergency Number: 800-524-0294
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|| 100.0 ||200-662-2
Hazard Symbols: XI F
Risk Phrases: 11 36 66 67
Section 3 - Hazards Identification
Appearance: colourless. Flash Point: -4 deg F.
Causes respiratory tract irritation. Causes eye irritation.
Breathing vapors may cause drowsiness and dizziness. Prolonged or
repeated contact may dry the skin and cause irritation.
Danger! Extremely flammable liquid and vapor. Vapor may
cause flash fire.
Target Organs: Central nervous system,
respiratory system, eyes, skin.
Potential Health Effects
Produces irritation, characterized by a burning sensation, redness,
tearing, inflammation, and possible corneal injury.
May be absorbed through the skin. Repeated or prolonged exposure may
cause drying and cracking of the skin.
May cause irritation of the digestive tract. May cause central
nervous system depression, characterized by excitement, followed by
headache, dizziness, drowsiness, and nausea. Advanced stages may
cause collapse, unconsciousness, coma and possible death due to
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes respiratory tract irritation. May cause motor
incoordination and speech abnormalities.
Prolonged or repeated skin contact may cause dermatitis. Chronic
inhalation may cause effects similar to those of acute inhalation.
Section 4 - First Aid Measures
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists. Wash clothing before reuse.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical aid. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases may
be generated by thermal decomposition or combustion. Use water spray
to keep fire-exposed containers cool. May be ignited by heat,
sparks, and flame. Vapors are heavier than air and may travel to a
source of ignition and flash back. Vapors can spread along the ground
and collect in low or confined areas.
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. For large fires, use water spray, fog, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective. Do NOT use straight streams of
water. Cool containers with flooding quantities of water until well
after fire is out.
Flash Point: -4e deg F ( -20.00 deg C)
Autoignition Temperature: 869 deg F ( 465.00 deg C)
Explosion Limits, Lower:2.5%
(estimated) Health: 1; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated
in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Wear appropriate protective clothing
to minimize contact with skin. Remove all sources of ignition.
Provide ventilation. A vapor suppressing foam may be used to reduce
vapors. Water spray may reduce vapor but may not prevent ignition in
closed spaces. Clean up residual material by washing area with a 2-5%
solution of soda ash.
Section 7 - Handling and Storage
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Keep container tightly closed. Avoid ingestion and
inhalation. Do not pressurize, cut, weld, braze, solder, drill,
grind, or expose empty containers to heat, sparks or open flames. Use
only with adequate ventilation. Keep away from heat, sparks and
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Section 8 - Exposure Controls, Personal Protection
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
||OSHA - Final PELs|
|Acetone||500 ppm TWA; 750 ppm STEL
||250 ppm TWA; 590 mg/m3 TWA 2500 ppm IDLH||1000 ppm TWA; 2400 mg/m3 TWA
OSHA Vacated PELs:
750 ppm TWA; 1800 mg/m3 TWA
Personal Protective Equipment
Wear chemical goggles.
Wear appropriate protective gloves to prevent skin
Wear appropriate protective clothing to prevent skin
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Always use
a NIOSH or European Standard EN 149 approved
respirator when necessary.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Vapor Pressure: 180 mm Hg
Vapor Density: 2.0 (Air=1)
Evaporation Rate:7.7 (n-Butyl acetate=1)
Viscosity: Not available
Boiling Point: 133.2 deg F
Freezing/Melting Point:-139.6 deg F
Decomposition Temperature:Not available.
Specific Gravity/Density:0.79 (Water=1)
Section 10 - Stability and Reactivity
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
High temperatures, ignition sources, temperatures above 220°C.
Incompatibilities with Other Materials:
Strong acids, strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
CAS# 67-64-1: AL3150000
Dermal, guinea pig: LD50 = >9400 uL/kg;
test, rabbit, eye: 10 uL Mild;
Draize test, rabbit, eye: 20 mg
Draize test, rabbit, eye: 20 mg/24H Moderate;
test, rabbit, skin: 500 mg/24H Mild;
Inhalation, mouse: LC50 = 44
Inhalation, rat: LC50 = 50100 mg/m3/8H;
mouse: LD50 = 3 gm/kg;
Oral, rabbit: LD50 = 5340 mg/kg;
rat: LD50 = 5800 mg/kg;
ACGIH: A4 - Not Classifiable as a Human Carcinogen
No information available.
No information available.
TDLo(Oral, rat) = 273 gm/kg;Reproductive - Paternal Effects -
spermatogenesis (incl. genetic material, sperm morphology, motility,
No information available.
Sex chromosome loss and nondisjunction(Yeast - Saccharomyces
cerevisiae) = 47600 ppm; Cytogenetic analysis(Rodent - hamster
Fibroblast)= 40 gm/L.
Standard Draize Test: Administration onto the skin (human)
= 500 mg/7days (Mild). Standard Draize Test: Administrat
ion onto the skin (rabbit) = 500 mg/24H (Mild). Standard D
raize Test( Eye, Rabbit) = 20 mg; Severe.
Section 12 - Ecological Information
Material Safety Data Sheet Brown trout: ; ;
Rainbow trout LC50=5540 mg/L/96H Sunfish (tap water), death at 14250
ppm/24H Mosquito fish (turbid water) TLm=13000 ppm/48HCas#
67-64-1:LC50 (96Hr.) rainbow trout = 5540 mg/L; Static conditions,
11-13 degrees CLC50 (96Hr) Fathead Minnow = 7280-8120 mg/L;
Flow-through ConditionsLC50 (96Hr) Bluegill = 8300 mg/L
Volatilizes, leeches, and biodegrades when released to soil.
TERRESTRIAL FATE: If released on soil, acetone will both volatilize
and leach into the ground. Acetone readily biodegrades and there is
evidence suggesting that it biodegrades fairly rapidly in soils.
AQUATIC FATE: If released into water, acetone will probably
biodegrade. It is readily biodegradable in screening tests, although
data from natural water are lacking. It will also be lost due to
volatilization (estimated half-life 20 hr from a model river).
Adsorption to sediment should not be significant.
ATMOSPHERIC FATE: In the atmosphere, acetone will be lost by
photolysis and reaction with photochemically produced hydroxyl
radicals. Half-life estimates from these combined processes are 79
and 13 days in January and June, respectively, for an overall annual
average of 22 days. Therefore considerable dispersion should occur.
Being miscible in water, wash out by rain should be an important
removal process. This process has been confirmed around Lake
Shinsei-ko in Japan. There acetone was found in the air and rain as
well as the lake.
Not expected to bioconcentrate in fish. he recommended log
octanol/water partition coefficient for acetone is -0.24 and
therefore its potential for bioconcentration in fish is negligible.
One experimental study of bioconcentration in adult haddock at 7-9
deg C (static test), resulted in a BCF of 0.69.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 67-64-1: waste number
U002 (Ignitable waste).
Section 14 - Transport Information
||No information available.
||FLASHPOINT -20 C|
Section 15 - Regulatory Information
CAS# 67-64-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
CAS# 67-64-1: 4/12b
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 67-64-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
CAS # 67-64-1: acute, chronic, flammable.
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
None of the chemicals in this product are considered highly hazardous
CAS# 67-64-1 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
California No Significant Risk Level:
None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 11 Highly flammable.
R 36 Irritating to eyes.
R 66 Repeated exposure may cause skin dryness or
R 67 Vapors may cause drowsiness and dizziness.
S 16 Keep away from sources of ignition - No
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 9 Keep container in a well-ventilated place.
WGK (Water Danger/Protection)
CAS# 67-64-1: 0
Canada - DSL/NDSL
CAS# 67-64-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
Canadian Ingredient Disclosure List
CAS# 67-64-1 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-64-1: OEL-AUSTRALIA:TWA 500 ppm (1185 mg/m3);STEL 1000 ppm
OEL-AUSTRIA:TWA 750 ppm (1780 mg/m3) OEL-BELGIUM:TWA 750 ppm (1780 mg
/m3);STEL 1000 pp OEL-CZECHOSLOVAKIA:TWA 800 mg/m3;STEL 4000 mg/m3 O
EL-DENMARK:TWA 250 ppm (600 mg/m3) OEL-FINLAND:TWA 500 ppm (1200 mg/m
3);STEL 625 ppm (1500 mg/m3) OEL-FRANCE:TWA 750 ppm (1800 mg/m3) OEL
-GERMANY:TWA 1000 ppm (2400 mg/m3) OEL-HUNGARY:TWA 600 mg/m3;STEL 120
0 mg/m3 OEL-INDIA:TWA 750 ppm (1780 mg/m3);STEL 1000 ppm (2375 mg/m3)
OEL-JAPAN:TWA 200 ppm (470 mg/m3) OEL-THE NETHERLANDS:TWA 750 ppm (
1780 mg/m3) JAN9 OEL-THE PHILIPPINES:TWA 1000 ppm (2400 mg/m3) OEL-P
OLAND:TWA 200 mg/m3 OEL-RUSSIA:TWA 200 ppm;STEL 200 mg/m3 OEL-SWEDEN
:TWA 250 ppm (600 mg/m3);STEL 500 ppm (1200 mg/m3) OEL-SWITZERLAND:TW
A 750 ppm (1780 mg/m3) OEL-TURKEY:TWA 1000 ppm (2400 mg/m3) OEL-UNIT
ED KINGDOM:TWA 750 ppm (1810 mg/m3);STEL 1250 ppm OEL IN BULGARIA, CO
LOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE,
VIETNAM check ACGI TLV
Section 16 - Additional Information
MSDS Creation Date: 7/26/1999
Revision #7 Date: 2/26/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.